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Irena Cosic, Drasko Cosic and Ivan Loncarevic
The results of this research can be used for understanding how SARS-CoV-2 infects human cells, particularly in severe cases of COVID-19 and, consequently, this research can aid the development of new treatments.
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Enetia Disberia Bobo, Pias Munosiyei, Percy Jinga, Emmanuel Zingoni
Pág. 38 - 47
An understanding of the function of signaling genes/proteins in soybean is vital for comprehending plant growth and development. The objective of this study was to functionally characterize a calmodulin-binding receptor-like cytoplasmic kinase gene (Glym...
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Igor D. Diankin,Denis S. Kudryavtsev,Arthur O. Zalevsky,Victor I. Tsetlin,Andrey V. Golovin
Pág. 73 - 77
SLURP-1 is a member of three-finger toxin-like proteins. Their characteristic feature is a set of three beta strands extruding from hydrophobic core stabilized by disulfide bonds. Each beta-strand carries a flexible loop, which is responsible for r...
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Christoph Gorgulla,Konstantin Fackeldey,Gerhard Wagner,Haribabu Arthanari
Structure-based virtual screening approaches have the ability to dramatically reduce the time and costs associated to the discovery of new drug candidates. Studies have shown that the true hit rate of virtual screenings improves with the scale of the scr...
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Christoph Gorgulla,Konstantin Fackeldey,Gerhard Wagner,Haribabu Arthanari
Structure-based virtual screening approaches have the ability to dramatically reduce the time and costs associated to the discovery of new drug candidates. Studies have shown that the true hit rate of virtual screenings improves with the scale of the scr...
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Chia-Hung Tsai, Kuang-Teng Wang, Xuan Guo and Tsung-Meng Wu
The shark-derived single-domain antibody VNAR (variable domain of new antigen receptor) has many advantageous features that make the VNAR suitable for improving current monoclonal antibody therapy deficiencies or disease diagnosis methods. In order to di...
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Stefanie Ranf
Infestations of crop plants with pathogens pose a major threat to global food supply. Exploiting plant defense mechanisms to produce disease-resistant crop varieties is an important strategy to control plant diseases in modern plant breeding and can grea...
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Bianca Venter, Cornelius C. Bezuidenhout
Pág. 1 bladsy
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B. Venter, C.C. Bezuidenhout
Pág. 1 bladsy
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Matthew Tunbridge and Pedro Henrique França Gois
Vitamin D (VD) is a steroid hormone classically known for its key role in maintaining calcium homeostasis in the body. VD also has important immunomodulatory functions. This review explores evidence for a role of VD in attenuating the activation of the n...
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Jun Song, Brooke Pallas, Dongshan Yang, Jifeng Zhang, Yash Agarwal, Y. Eugene Chen, Moses Bility and Jie Xu
Production of immunodeficient (ID) models in non-murine animal species had been extremely challenging until the advent of gene-editing tools: first zinc finger nuclease (ZFN), then transcription activator-like effector nuclease (TALEN), and most recently...
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Zhongjie Wang, Jihai Shao, Yao Xu, Biao Yan and Renhui Li
Geosmin is a common, musty-smelling sesquiterpene, principally produced by cyanobacteria. Anabaena ucrainica (Schhorb.) Watanabe, a water bloom-forming cyanobacterium, is the geosmin producer responsible for odor problems in Dianchi and Erhai lakes in Ch...
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Rachel Siqueira de Queiroz Simões and David Rodríguez-Lázaro
Several coronaviruses (CoVs) have been identified as human pathogens, including the a-CoVs strains HCoV-229E and HCoV-NL63 and the ß-CoVs strains HCoV-HKU1 and HCoV-OC43. SARS-CoV, MERS-CoV, and SARS-CoV-2 are also classified as ß-coronavirus. New SARS-C...
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Qiansheng Huang, Huanteng Zhang, Ya-Jie Chen, Yu-Lang Chi and Sijun Dong
Epidemiological studies have shown the possible link between phthalates and endometrium-related gynecological diseases, however the molecular mechanism(s) behind this is/are still unclear. In the study, both primary cultured endometrial cells and an endo...
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Chih-Jan Ko, Chia-Jung Li, Meng-Yu Wu and Pei-Yi Chu
Hepatocarcinogenesis and distant metastasis pose major challenges for physicians. They are regulated by several genes, such as AKT, JUK, Wnt, and P53, and their expression activates several important processes such as cell proliferation, migration, motil...
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Yuanyuan Zhang, Youxin Yu, Meiqi Xu, Jingyan Liao, Chenjia Shao, Liran Fu, Mingshi Qian, Gang Xu and Guoqing Yang
The rice stripe virus (RSV) is transmitted by the small brown planthopper Laodelphax striatellus in a persistent and circulative?propagative manner. During the last few decades, RSV has caused serious disease outbreaks in rice fields in China. The result...
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Fatmah A. Safhi and Ahmed Ateya
This study examined the genes related to immunity, metabolism, and antioxidants that may interact with the prevalence of postpartum endometritis in Ossimi sheep. We used fifty endometritis-positive Ossimi sheep and fifty that appeared to be normal. For t...
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Jiaming Li, Yuhan Ma, Zhichao Yang, Fengchi Wang, Jialin Li, Yusheng Jiang, Dazuo Yang, Qilin Yi and Shu Huang
The Forkhead Box O (FOXO) gene plays a key role in various biological processes, such as growth, metabolism, development, immunity and longevity. Molting is an essential process for crustacean growth, which is mainly regulated by 20-hydroxyecdysone (20E)...
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Li-Xin Ma, Rong-Tao He, Shu-Yan Yan and Wen-Jia Yang
Hormone receptor 3 (HR3), an early-late gene of the 20-hydroxyecdysone (20E) signaling pathway, plays a critical role in insect metamorphosis and development. In this study, we identified and characterized an HR3 gene (LsHR3) from the cigarette beetle, L...
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Brigitte Sipos, Peter Jirak, Vera Paar, Richard Rezar, Moritz Mirna, Kristen Kopp, Uta C. Hoppe, Alexander E. Berezin and Michael Lichtenauer
Cardiovascular diseases remain the most common causes of death globally, according to the World Health Organization. In recent years, a great number of biomarkers have been investigated, whereas only some have gained value in the diagnosis, prognosis, an...
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