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Gennaro Vessio
Studying the effects of neurodegeneration on handwriting has emerged as an interdisciplinary research topic and has attracted considerable interest from psychologists to neuroscientists and from physicians to computer scientists. The complexity of handwr...
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Rosa Senatore, Antonio Della Cioppa and Angelo Marcelli
Background: The use of Artificial Intelligence (AI) systems for automatic diagnoses is increasingly in the clinical field, being a useful support for the identification of several diseases. Nonetheless, the acceptance of AI-based diagnoses by the physici...
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Rosa Senatore, Antonio Della Cioppa and Angelo Marcelli
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Maria Dyah Nur Meinita, Dicky Harwanto and Jae-Suk Choi
Seaweeds or marine macroalgae are known for producing potentially bioactive substances that exhibit a wide range of nutritional, therapeutic, and nutraceutical properties. These compounds can be applied to treat chronic diseases, such as cancer, cardiova...
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Alberto J. Nuñez-Selles, Lauro Nuevas-Paz and Gregorio Martínez-Sánchez
Metal?mangiferin complexes as antioxidant and protecting agents against protein oxidative damage in adjuvant therapies of pathologies of high morbidity and mortality: neurodegenerative diseases, cancer, diabetes, and cardiovascular disorders.
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Dina Zidan and Azrina Azlan
Non-centrifugal sugar (NCS) is the scientific term the Food and Agriculture Organization (FAO) uses to define a solid product, produced by sugarcane juice evaporation, which is unrefined or minimally refined. NCS is referred to in various names globally,...
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Cristina Ramona Novaconi, Robert Onulov, Alina Florina Serb, Eugen Sisu, Nicolae Dinca, Mihai-Cosmin Pascariu and Marius Georgescu
Glycosphingolipids (GSLs) are a glycolipid subtype which plays vital roles in numerous biological processes, cell?cell interactions, as well as oncogenesis and ontogenesis. They are ubiquitous molecules found mostly in cell membranes. Abnormal expression...
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Zhaoyi Chen, Yuchen Yang, Dazheng Zhang, Jingchuan Guo, Yi Guo, Xia Hu, Yong Chen and Jiang Bian
Alzheimer?s disease (AD) and AD-related dementias (AD/ADRD) are a group of progressive neurodegenerative diseases. The progression of AD can be conceptualized as a continuum in which patients progress from normal cognition to preclinical AD (i.e., no sym...
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Lucía Soliño, Sea-Yong Kim, Alfredo López, Pablo Covelo, Sara Rydberg, Pedro Reis Costa and Sandra Lage
The neurotoxin ß-N-methylamino-L-alanine (BMAA), a non-proteinogenic amino acid produced by several species of both prokaryotic (cyanobacteria) and eukaryotic (diatoms) microorganisms, has been proposed to be associated with the development of neurodegen...
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Min Hye Kang, Yun-Jeong Ji, Yu Mi Han, Gwi Yeong Jang, Dong Hwi Kim, Jeong Hoon Lee, Geum-Soog Kim, Su Ji Choi and Hyung Don Kim
The overproduction of reactive oxygen species (ROS) can cause oxidative stress to biomolecules such as nucleic acids, proteins, and lipids, leading to neurodegenerative disorders. Sasa borealis (SB) has antioxidant, anti-inflammatory, antidiabetic, and a...
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Tiffany T. Ly, Jie Wang, Kanchan Bisht, Ukpong Eyo and Scott T. Acton
Automatic glia reconstruction is essential for the dynamic analysis of microglia motility and morphology, notably so in research on neurodegenerative diseases. In this paper, we propose an automatic 3D tracing algorithm called C3VFC that uses vector fiel...
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Miey Park, So-Hyeun Kim and Hae-Jeung Lee
Alzheimer?s disease (AD) is a neurodegenerative disorder characterized by the accumulation of ß-amyloid plaques and hyperphosphorylated tau proteins in the brain. Cell signaling pathways such as PI3K/Akt are known to play an essential role in regulating ...
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Alessia Sarica, Maria Grazia Vaccaro, Andrea Quattrone and Aldo Quattrone
Cluster analysis is widely applied in the neuropsychological field for exploring patterns in cognitive profiles, but traditional hierarchical and non-hierarchical approaches could be often poorly effective or even inapplicable on certain type of data. Mo...
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Artur Chudzik and Andrzej W. Przybyszewski
Neurodegenerative diseases (NDs), including Parkinson?s and Alzheimer?s disease, pose a significant challenge to global health, and early detection tools are crucial for effective intervention. The adaptation of online screening forms and machine learnin...
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Jingeun Kim, Hye-Jin Park and Yourim Yoon
Parkinson?s disease is a neurodegenerative disease that is associated with genetic and environmental factors. However, the genes causing this degeneration have not been determined, and no reported cure exists for this disease. Recently, studies have been...
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Carmela Conte, Marzia Sichetti and Giovanna Traina
Many studies highlighted that a bidirectional communication between the gut and the central nervous system (CNS) exists. A vigorous immune response to antigens must be avoided, and pathogenic organisms crossing the gut barrier must be detected and killed...
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Saraswati Sridhar and Vidya Manian
Electroencephalogram signals are used to assess neurodegenerative diseases and develop sophisticated brain machine interfaces for rehabilitation and gaming. Most of the applications use only motor imagery or evoked potentials. Here, a deep learning netwo...
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Jusik Park, Wookwang Cheon and Kijin Kim
To investigate the effects of long-term lithium treatment and low intensity endurance exercise on brain-derived neurotrophic factor (BDNF) expression and glycogen synthase kinase 3 beta (GSK3ß) activity in the hippocampus of obese rats. Fifty 10-week-old...
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Lin Tan, Suxia Guo, Funing Ma, Chen Chang and Isabel Gómez-Betancur
Acetylcholinesterase is one of the most important enzymes in living organisms, which is responsible for the synapse cholinergic and other nervous processes. However, its inhibiting effects have proven to have pharmacological applications in the treatment...
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Haya I. Aljohar, Abdulmajeed A. Alghamdi, Nasr Y. Khalil, Hany W. Darwish, Rashad Al-Salahi and Ibrahim A. Darwish
The Food and Drug Administration (FDA) has approved duvelisib (DUV) for managing follicular lymphoma, small lymphocytic lymphoma, and relapsed or refractory chronic lymphocytic leukemia. Seliciclib (SEL) is a candidate drug for these cancers, neurodegene...
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