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You Sheng Toh and Carol Anne Hargreaves
Extensive medical research has revealed evidence of a strong association between hippocampus atrophy and age-related diseases such as Alzheimer?s disease (AD). Therefore; segmentation of the hippocampus is an important task that can help clinicians and r...
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Juan Jiang, Hong Liu, Xin Yu, Jin Zhang, Bing Xiong and Lidan Kuang
Precisely segmenting the hippocampus from the brain is crucial for diagnosing neurodegenerative illnesses such as Alzheimer?s disease, depression, etc. In this research, we propose an enhanced hippocampus segmentation algorithm based on 3D U-Net that can...
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Myung-Joon Kim, Hyun-Woo Kim, Soo-Rin Lee, Na-Yeong Kim, Yoon-Ji Lee, Hui-Tae Joo, Seok-Nam Kwak and Sang-Heon Lee
The feeding and spawning grounds for seahorses have been lost due to nationwide coastal developments in South Korea. However, little information on the feeding ecology of the Korean seahorse (Hippocampus haema) is currently available. The main objective ...
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Jusik Park, Wookwang Cheon and Kijin Kim
To investigate the effects of long-term lithium treatment and low intensity endurance exercise on brain-derived neurotrophic factor (BDNF) expression and glycogen synthase kinase 3 beta (GSK3ß) activity in the hippocampus of obese rats. Fifty 10-week-old...
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Céline Dinocourt, Cécile Culeux, Marie Legrand, Christelle Elie and Philippe Lestaevel
Uranium exposure leads to cerebral dysfunction involving for instance biochemical, neurochemical and neurobehavioral effects. Most studies have focused on mechanisms in uranium-exposed adult animals. However, recent data on developing animals have shown ...
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Zhen Jia, Yongjie Wei, Xiaoqian Li, Lixin Yang, Huijie Liu, Chen Guo, Lulu Zhang, Nannan Li, Shaojuan Guo, Yan Qian and Zhigang Li
Epidemiology studies indicated that air pollution has been associated with adverse neurological effects in human. Moreover, the secretion of glucocorticoid (GC) affects the mood regulation, and the negative feedback of hippocampal glucocorticoid receptor...
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Denise M. T. Yu, Stephanie Dauth, Michael B. Margineanu, Valentina Snetkova, Maren Rehders, Silvia Jordans and Klaudia Brix
Endolysosomal cathepsin expression and activities are differentially regulated in the cortex, striatum, hippocampus, and cerebellum of mice upon aging and/or cathepsin deficiencies.
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Sungeun Melanie Lee, Michaela M. Milillo, Beatrix Krause-Sorio, Prabha Siddarth, Lisa Kilpatrick, Katherine L. Narr, Jonathan P. Jacobs and Helen Lavretsky
Growing evidence supports the concept that bidirectional brain?gut microbiome interactions play an important mechanistic role in aging, as well as in various neuropsychiatric conditions including depression. Gray matter volume (GMV) deficits in limbic re...
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Jong Min Oh, Moongi Ji, Mi-Jin Lee, Geum Seok Jeong, Man-Jeong Paik, Hoon Kim and Joo-Won Suh
The antidepressant-like activity of ethanol extract of Ziziphus jujuba Mill var. spinosa seeds (Semen Ziziphi Spinosae, SZS) was investigated by behavioral tests, such as a forced swimming test (FST), a tail-suspension test (TST), and an open field test ...
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Fabiana Novellino, Maria Salsone, Roberta Riccelli, Carmelina Chiriaco, Giuseppe Argirò, Andrea Quattrone, José L. M. Madrigal, Luigi Ferini Strambi and Aldo Quattrone
This study aimed to investigate the structural covariance between the striatum and large-scale brain regions in patients with vascular parkinsonism (VP) compared to Parkinson?s disease (PD) and control subjects, and then explore the relationship between ...
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Hae-Jin Lee, Hae-Lim Kim, Dae-Young Lee, Dong-Ryung Lee, Bong-Keun Choi and Seung-Hwan Yang
We evaluated the effectiveness of Scrophularia buergeriana extract (Brainon) on cognitive dysfunction and determined its underlying mechanisms in a scopolamine (SCO)-treated mouse model of memory impairment. Brainon treatment for 28 days ameliorated the ...
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Rong Zhou, Zhisheng Zhang and Yuan Wang
Deep reinforcement learning is one of the research hotspots in artificial intelligence and has been successfully applied in many research areas; however, the low training efficiency and high demand for samples are problems that limit the application. Ins...
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Lin Tan, Suxia Guo, Funing Ma, Chen Chang and Isabel Gómez-Betancur
Acetylcholinesterase is one of the most important enzymes in living organisms, which is responsible for the synapse cholinergic and other nervous processes. However, its inhibiting effects have proven to have pharmacological applications in the treatment...
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Yufei Mei, Chunli Duan, Xiaoxiao Li, Yun Zhao, Fenghua Cao, Shuai Shang, Shumao Ding, Xiangpei Yue, Ge Gao, Hui Yang, Luxi Shen, Xueyan Feng, Jianping Jia, Zhiqian Tong and Xu Yang
Individuals afflicted with occupational formaldehyde (FA) exposure often suffer from abnormal behaviors such as aggression, depression, anxiety, sleep disorders, and in particular, cognitive impairments. Coincidentally, clinical patients with melatonin (...
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Robert Siblerud, Joachim Mutter, Elaine Moore, Johannes Naumann and Harald Walach
Mercury is one of the most toxic elements and causes a multitude of health problems. It is ten times more toxic to neurons than lead. This study was created to determine if mercury could be causing Alzheimer?s disease (AD) by cross referencing the effect...
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