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Ill-Min Chung, Govindasamy Rajakumar, Umadevi Subramanian, Baskar Venkidasamy and Muthu Thiruvengadam
Gymnema sylvestre is a plant that is enriched in bioactive compounds. In particular, gymnemic acids (GA) and phenolic compounds (PC) are pharmaceutically important. There is a commercial demand for naturally occurring bioactive compounds, but their avail...
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Dmitry S. Druzhilovskiy,Leonid A. Stolbov,Polina I. Savosina,Pavel V. Pogodin,Dmitry A. Filimonov,Alexander V. Veselovsky,Karen Stefanisko,Nadya I. Tarasova,Marc C. Nicklaus,Vladimir V. Poroikov
To improve the discovery of more effective and less toxic pharmaceutical agents, large virtual repositories of synthesizable molecules have been generated to increase the explored chemical-pharmacological space diversity. Such libraries include billions ...
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Dmitry S. Druzhilovskiy,Leonid A. Stolbov,Polina I. Savosina,Pavel V. Pogodin,Dmitry A. Filimonov,Alexander V. Veselovsky,Karen Stefanisko,Nadya I. Tarasova,Marc C. Nicklaus,Vladimir V. Poroikov
To improve the discovery of more effective and less toxic pharmaceutical agents, large virtual repositories of synthesizable molecules have been generated to increase the explored chemical-pharmacological space diversity. Such libraries include billions ...
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Long Bao, Xuemei Zhao, Gaowa Kang, Kaito Suzuki, Tamer Ismail, Yoshiharu Fujii and Satoru Motoki
Platycodon is a medicinal plant of considerable pharmacological and dietary value. With the growing demand, agricultural production is increasing. However, the continuous cropping significantly causes negative impacts on its yield and quality. In this st...
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Gloria Perazzoli, Carolina de los Reyes, Cristina Pinedo-Rivilla, Rosa Durán-Patrón, Josefina Aleu, Laura Cabeza, Consolación Melguizo and Jose Prados
The marine environment is a promising source of natural products with possible pharmacological applications. In this sense, marine microorganisms, especially marine fungi, can produce bioactive compounds with various therapeutic properties. Colorectal ca...
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En-Shyh Lin and Cheng-Yang Huang
Plinia cauliflora has been associated with numerous ethnobotanical applications. In this study, we uncovered that the fruit extract of P. cauliflora, obtained using 50% ethanol, possesses inhibition activity against the Klebsiella pneumoniae single-stran...
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Mohammed Bouslamti, Amal Elrherabi, El Hassania Loukili, Omar M. Noman, Ramzi A. Mothana, Mansour N. Ibrahim, Rhizlan Abdnim, Meryem Slighoua, Mohamed Bouhrim, Mohamed Bnouham, Badiaa Lyoussi and Ahmed Samir Benjelloun
In the present investigation, the phenolic compounds of Solanum elaeagnifolium were identified, and the plant?s anti-lipase and anti-glycation effects on hemoglobin were discovered through in vitro experiments, as well as its short-term antihyperglycemic...
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Chih-Wei Hsia, Wei-Chieh Huang, Chih-Hao Yang, Chih-Hsuan Hsia, Thanasekaran Jayakumar, Periyakali Saravana Bhavan, Joen-Rong Sheu and Kuan-Rau Chiou
Myocardial infarction and cerebral ischemic stroke are prominent causes of death worldwide. Platelets play major roles in these diseases, although they are anucleated cells, but also express the NF-?B. Pterostilbene (PTE) possesses some intriguing pharma...
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Lin Tan, Suxia Guo, Funing Ma, Chen Chang and Isabel Gómez-Betancur
Acetylcholinesterase is one of the most important enzymes in living organisms, which is responsible for the synapse cholinergic and other nervous processes. However, its inhibiting effects have proven to have pharmacological applications in the treatment...
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K N Agel, E Abood, T Alsalim
Pág. 1 - 13
Introduction: Curcumin is a yellow pigment extracted from the Curcuma longa L, which have a several biological activities and pharmacological properties. Curcuminoids have a wide range as antioxidant not only in a food system, but also for biological sys...
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Itumeleng H. Mabusa, Rachmond Howard, Peter Masoko
Pág. 8 bladsye
Sutherlandia frutescens (L) R. Br. contains several essential, bioactive compounds with clinically proven pharmacological activities. Sutherlandia is prescribed for people with tuberculosis but it is still not known what compounds in this plant...
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José Ariévilo Gurgel Rodrigues, Edfranck de Sousa Oliveira Vanderlei, Ana Luíza Gomes Quinderé, Valdécio Silvano Monteiro, Silvânia Maria Mendes de Vasconcelos, Norma Maria Barros Benevides
Pág. 417 - 425
Caulerpa cupressoides var. lycopodium (Chlorophyta) contains three sulfated polysaccharides (SPs) fractions (SP1, SP2 and SP3); but, their pharmacological properties have been limited. We investigated the antinociceptive activity of non-anticoagulant fra...
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Laura Mosca, Francesca Vitiello, Martina Pagano, Alessandra Coppola, Roberta Veglia Tranchese, Roberta Grillo, Giovanna Cacciapuoti and Marina Porcelli
Squamous cell carcinoma of the head and neck (HNSCC), which includes cancers of the oral cavity and larynx, is one of the most common and highly aggressive malignancies worldwide, despite significant efforts committed in recent decades in its detection, ...
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Adriana Mirela Tache, Laura Dorina Dinu and Emanuel Vamanu
Urinary tract infections (UTI) represent one of the most widespread infections, and frequent recurrent episodes, induced mostly by uropathogenic Escherichia coli, make them increasingly difficult to treat. Long-term antibiotic therapy is an effective app...
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Dorina Lauritano, Giulia Moreo, Fedora Della Vella, Annalisa Palmieri, Francesco Carinci and Massimo Petruzzi
Background: It has been proven that the antihypertensive agent nifedipine can cause gingival overgrowth as a side effect. The aim of this study was to analyze the effects of pharmacological treatment with nifedipine on human gingival fibroblasts activity...
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Ali Irfan, Sami Ullah, Ayesha Anum, Nazish Jabeen, Ameer Fawad Zahoor, Hafza Kanwal, Katarzyna Kotwica-Mojzych and Mariusz Mojzych
The 1,2,3-thiadiazole moiety occupies a significant and prominent position among privileged heterocyclic templates in the field of medicine, pharmacology and pharmaceutics due to its broad spectrum of biological activities. The 1,2,3-thiadiazole hybrid s...
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Ali Irfan, Sajjad Ahmad, Saddam Hussain, Fozia Batool, Haseeba Riaz, Rehman Zafar, Katarzyna Kotwica-Mojzych and Mariusz Mojzych
Quinoxaline is a privileged pharmacophore that has broad-spectrum applications in the fields of medicine, pharmacology and pharmaceutics. Similarly, the sulfonamide moiety is of considerable interest in medicinal chemistry, as it exhibits a wide range of...
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Chahla Benbrahim, Mohammed Salih Barka, Adriana Basile, Viviana Maresca, Guido Flamini, Sergio Sorbo, Federica Carraturo, Rosaria Notariale, Marina Piscopo, Abdelmounaim Khadir, Asma Zatout and Sara Mechaala
Folk medicine uses wild herbs, especially from the Lamiaceae family, such as oregano and lavender, in the treatment of many diseases. In the present study, we investigated the antibacterial activity of the essential oils of Origanum glandulosum Desf. and...
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Felicia Suciu, Iuliana Stoicescu, Elena Carmen Lupu, Antoanela Popescu, Adrian Cosmin Ro?ca, Florentina Nicoleta Roncea, Denisa-Elena Dumitrescu, Victoria Badea and Florin Ciprian Badea
The aim is to evaluate the antibacterial and antifungal properties of the extracts obtained from Lysimachia nummularia L. in order to be able to introduce these extracts into pharmaceutical products and obtain useful products in the infectious and antifu...
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Ízola Morais de Medeiros Ramalho, Gabriela Suassuna Bezerra, Elissa Arantes Ostrosky, Márcio Ferrari, Verônica da Silva Oliveira, Alcides de Oliveira Wanderley Neto, Jullyana de Souza Siqueira Quintans, Fabiolla Rocha Santos Passos, Luana Heimfarth, Lucindo José Quintans-Júnior, Bolívar Ponciano Goulart de Lima Damasceno, Attilio Converti and Ádley Antonini Neves de Lima
Chrysin is a bioactive flavonoid found in pollens, passion flowers, honey, royal jelly, and propolis, which is commonly used as an ingredient in natural food supplements and is primarily responsible for their pharmacological properties. A transparent chr...
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