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Cristobal Aguilar-Gallardo and Ana Bonora-Centelles
Cell and gene therapies represent promising new treatment options for many diseases, but also face challenges for clinical translation and delivery. Hospital-based GMP facilities enable rapid bench-to-bedside development and patient access but require si...
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Ruta Palep?iene, Martynas Maciulevicius, Paulius Ruzgys, Baltramiejus Jak?tys and Saulius ?atkauskas
Gene electrotransfer (GET) is recognized as a promising technique for the development of an efficient tool for gene therapy. Such a therapy would have applications in the treatment of a variety of genetic diseases, including cancer. However, despite its ...
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Michele Basilicata, Giulia Marrone, Manuela Di Lauro, Eleonora Sargentini, Vincenza Paolino, Redan Hassan, Giuseppe D?Amato, Patrizio Bollero and Annalisa Noce
Gaucher disease (GD) is a lysosomal storage pathological condition, characterized by a genetic autosomal recessive transmission. The GD cause is the mutation of GBA1 gene, located on the chromosome 1 (1q21), that induces the deficiency of the lysosomal e...
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Chang Kyu Lee, Dong Hwa Heo, Hungtae Chung, Eun Ji Roh, Anjani Darai, Jae Won Kyung, Hyemin Choi, Su Yeon Kwon, Basanta Bhujel and Inbo Han
Intervertebral disc (IVD) degeneration is a leading cause of chronic low back pain (LBP) that results in serious disability and significant economic burden. IVD degeneration alters the disc structure and spine biomechanics, resulting in subsequent struct...
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Mario Ibrahin Gutierrez, Antonio Ramos, Josefina Gutierrez, Arturo Vera and Lorenzo Leija
Therapeutic focused ultrasound is a technique that can be used with different intensities depending on the application. For instance, low intensities are required in nonthermal therapies, such as drug delivering, gene therapy, etc.; high intensity ultras...
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Meiqi Wang, Dan Liu, Yunchuanxiang Huang, Ziyi Jiang, Feng Wu, Yu Cen and Lan Ma
Esophageal cancer (EC) is one of the deadliest cancers worldwide. However, reliable biomarkers for early diagnosis, or those for the prognosis of therapy, remain unfulfilled goals for its subtype esophageal squamous cell carcinoma (ESCC). The purpose of ...
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Baby Joseph,Ajisha S.U,Jeevitha M.V
Pág. 98 - 103
Abstract - RNA interference (RNAi) technology has become a novel tool for silencing gene expression in cells or organisms. RNA interference is the process that double-stranded RNA induces the homology-dependent degradation of cognate mRNA mediated by 21-...
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Christos Koroulis, Evangelos Makris, Angelos Kolaitis, Panayiotis Tsanakas and Christos Pavlatos
The observation and analysis of RNA molecules have proved crucial for the understanding of various processes in nature. Scientists have mined knowledge and drawn conclusions using experimental methods for decades. Leveraging advanced computational method...
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Joana Morgado, Tania Pereira, Francisco Silva, Cláudia Freitas, Eduardo Negrão, Beatriz Flor de Lima, Miguel Correia da Silva, António J. Madureira, Isabel Ramos, Venceslau Hespanhol, José Luis Costa, António Cunha and Hélder P. Oliveira
The evolution of personalized medicine has changed the therapeutic strategy from classical chemotherapy and radiotherapy to a genetic modification targeted therapy, and although biopsy is the traditional method to genetically characterize lung cancer tum...
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Marjan Bakhtiari-Nejad and Shima Shahab
Many biomedical applications such as ultrasonic targeted drug delivery, gene therapy, and molecular imaging entail the problems of manipulating microbubbles by means of a high-intensity focused ultrasound (HIFU) pressure field; namely stable cavitation. ...
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