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Fatih Demirel, Bünyamin Yildirim, Baris Eren, Serap Demirel, Aras Türkoglu, Kamil Haliloglu, Kamila Nowosad, Henryk Bujak and Jan Bocianowski
Investigating the genetic diversity and population structure of wheat germplasm is crucial for understanding the underlying variability essential for breeding programs and germplasm preservation. This research aims to contribute novel insights with respe...
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Hee-seung Hwang, Boongho Cho, Jaemin Cho, Beomseok Park and Taewon Kim
Hydrothermal vents are chemosynthetically driven ecosystems and one of the most extreme environments on Earth. Vent communities exhibit remarkable taxonomic novelty at the species and supra-species levels, and over 80% of vent species are endemic. Here, ...
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Nguyen Viet Phong, Byung Sun Min, Seo Young Yang and Jeong Ah Kim
We isolated eight known secondary metabolites, including two isocoumarins and six coumarins, from the stems and branches of Acer mono Maxim. Their structures were confirmed using nuclear magnetic resonance spectroscopy and by comparing the data to publis...
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Zsanett Dorkó, Anett Szakolczai, Blanka Tóth, George Horvai
Pág. 10 - 14
If the measured isotherm data of an adsorption system are well described by the Freundlich equation, then they can similarly well be described by the bi-Langmuir or tri-Langmuir model in most practical cases. This is proved by Monte Carlo simulation and ...
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Valentina D. Maslova,Roman V. Reshetnikov,Vladimir V. Bezugolov,Igor I. Lyubimov,Andrey V. Golovin
Pág. 98 - 102
An in silico approach was adopted to identify potential cyclooxygenase inhibitors through molecular docking studies. Four potentially active molecules were generated by fusion of dopamine with ibuprofen or ketorolac derivatives. The binding mode of the c...
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Yu Wang, Baozhu Dong, Dong Wang, Xinyu Jia, Qian Zhang, Wanyou Liu and Hongyou Zhou
(-)-Spirobrassinin, a glucosinolate compound from Brassicaceae plants, has shown inhibitory effects on weeds. However, its specific target sites are not well explored. This study used molecular docking, molecular dynamics simulations, and biological expe...
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Yi Wang, Meiqing Zhu, Jia Liu, Risong Na, Feng Liu, Xiangwei Wu, Shisuo Fan, Zhen Wang, Dandan Pan, Jun Tang, Qing X. Li, Rimao Hua and Shangzhong Liu
The interactions of dihydroquinazolines with human serum albumin (HSA) were studied in pH 7.4 aqueous solution via fluorescence, circular dichroism (CD) and Fourier transform infrared (FTIR) spectroscopic techniques. In this work, 6-chloro-1-(3,3-dimethy...
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Farahziatul Roshidah Nazri
Pág. 46
Ebola virus disease (EVD) is a threatening disease caused by the infection of Ebola virus (EBOV). EVD lead to severe post-infection conditions such as hemorrhagic fever and even death. Up to this day, there is still no officially approved vaccines or dru...
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Aras Türkoglu, Kamil Haliloglu, Metin Tosun, Piotr Szulc, Fatih Demirel, Baris Eren, Henryk Bujak, Halit Karagöz, Marek Selwet, Güller Özkan and Gniewko Niedbala
Wheat, which is scientifically known as Triticum aestivum L., is a very nutritious grain that serves as a key component of the human diet. The use of mutation breeding as a tool for crop improvement is a reasonably rapid procedure, and it generates a var...
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Hongbin Zhou, Junyu He, Mengyue Wang, Xintian Wang and Shengwei Chen
The Ynbs (Yunnan branched-spike) mutant of naked barley with a branched spike displays some special traits, such as more degenerated multiple spikelets per spike and florets per multiple spikelets and a lower seed-setting rate. However, there is still a ...
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Jesús Plácido Medina Salas, Francisco Gamarra Gómez, Elisban Juani Sacari Sacari, Wilson Orlando Lanchipa Ramos, Rocío María Tamayo Calderón, Efracio Mamani Flores, Víctor Yapuchura Platero, Walter Dimas Florez Ponce de León and Elmer Marcial Limache Sandoval
Arsenic (III) exposure, often from contaminated water, can have severe health repercussions. Chronic exposure to this toxic compound is linked to increased risks of various health issues. Various technologies exist for arsenic (III) removal from contamin...
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Ki Hyun Nam
Glucose isomerase (GI, also known as xylose isomerase) reversibly isomerizes D-glucose and D-xylose to D-fructose and D-xylulose, respectively. GI plays an important role in sugar metabolism, fulfilling nutritional requirements in bacteria. In addition, ...
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Yuan Yuan, Zhengfu Zhou, Yuhua Zhan, Xiubin Ke, Yongliang Yan, Min Lin, Pengcheng Li, Shijie Jiang, Jin Wang and Wei Lu
EPSP synthase is the target enzyme of glyphosate herbicides. Due to the extensive use of glyphosate, it is very important to obtain EPSPS genes with high glyphosate resistance for the development of transgenic crops. GR79-EPSPS is a class I EPSP synthase...
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Yeseul Park and Jin-Won Park
The binding between cinnamycin and the phosphatidylethanolamine (PE)-included vesicles was monitored using cyclic voltammetry (CV) measurements and interpreted in terms of the composition of the vesicles and the monolayer binding site. The monolayer was ...
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Isui Abril García-Montoya, Norma Rosario Flores-Holguín, Linda-Lucila Landeros-Martínez, Mónica Alvarado-González, Quintín Rascón-Cruz, María Elena Fuentes-Montero, Pedro Palomares-Báez and Luz María Rodríguez-Valdez
Mycotoxins known as aflatoxins (AF) are produced as a secondary metabolite by some species of Aspergillus fungi. They are considered carcinogenic, hepatotoxic, teratogenic, and mutagenic. In this study, the molecular structure, chemical reactivity, and c...
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Mohammed Zaghlool Al-Khayyat
Pág. 1 - 9
Introduction: Chorismate synthase catalyzes the final step in shikimate acid pathway involved in synthesis of aromatic compounds in bacteria. This enzyme can be a possible molecular target for design of antibiotics. Materials and Methods: Homology modeli...
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Alexey V. Sulimov,Danil C. Kutov,Vladimir B. Sulimov
Pág. 26 - 50
This review is based on the peer?reviewed research literature including the author?s own publications devoted to supercomputer docking. The general view on docking and its role at the initial stage of the rational drug design is presented. Molecules of m...
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Kyle Boone, Aya Kirahm Cloyd, Emina Derakovic, Paulette Spencer and Candan Tamerler
Collagen is fundamental to a vast diversity of health functions and potential therapeutics. Short peptides targeting collagen are attractive for designing modular systems for site-specific delivery of bioactive agents. Characterization of peptide?protein...
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Zhonghua Xia, Pavel Karpov, Grzegorz Popowicz, Michael Sattler and Igor V. Tetko
Small-molecule drug design aims to identify inhibitors that can specifically bind to a functionally important region on the target, i.e., an active site of an enzyme. Identification of potential binding pockets is typically based on static three-dimensio...
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Kanoknate M. Supasri, Manoj Kumar, Anna Segecová, Janice I. McCauley, Andrei Herdean, Matthew P. Padula, Tim O?Meara and Peter J. Ralph
Peridinin-Chlorophyll a-Proteins (PCP) are the major light harvesting proteins in photosynthetic dinoflagellates. PCP shows great variation in protein length, pigment ratio, sequence, and spectroscopic properties. PCP conjugates (PerCP) are widely used a...
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