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Zuguo Xi, Huiyan Jia, Yifan Li, Jinqing Ma, Mengqian Lu, Zhihui Wang, Dexu Kong and Wei-Wei Deng
Tea is a healthy beverage made from the leaves of the tea plant [Camellia sinensis (L.) O. Kuntze]. The tea plant is a perennial evergreen plant that is widely distributed in tropical and subtropical regions. PR proteins (pathogenesis-related proteins, P...
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Elliasu Y. Salifu, Mbuso A. Faya, James Abugri and Pritika Ramharack
Cancer remains a major challenge in the field of medicine, necessitating innovative therapeutic strategies. Mitogen-activated protein kinase (MAPK) signaling pathways, particularly Extracellular Signal-Regulated Kinase 1 and 2 (ERK1/2), play pivotal role...
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Ernesto Burgio, Prisco Piscitelli and Annamaria Colao
The dominant pathogenic model, somatic mutation theory (SMT), considers carcinogenesis as a ?genetic accident? due to the accumulation of ?stochastic? DNA mutations. This model was proposed and accepted by the scientific community when cancer mainly affe...
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Mawulikplimi Yao Adzavon, Pengxiang Zhao, Xujuan Zhang, Xin Zhang, Limin Wang, Tarekegn Gebreyesus Abisso, Xuemei Ma
Pág. 27 - 34
Despite a perpetual increase in the prevalence of benign lymphoepithelial lesion, data on the mechanisms governing its pathogenesis are still missing. Thus, we aimed in the present study to evaluate whether TLRs could regulate the expression of the pleio...
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Saleh A. Almatroodi, Amjad Ali Khan, Abdulaziz A. Aloliqi, Mansoor Ali Syed and Arshad Husain Rahmani
Chronic respiratory diseases are a leading cause of lung-related death worldwide. The vital factors causing lung pathogenesis include consistent exposure to tobacco smoke, air pollution, and occupational risks. Regarding the significant morbidity and mor...
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Wen-Chin Ko, Chia-Ti Tsai, Kai-Cheng Hsu, Yu-Che Cheng, Tony Eight Lin, Yi-Ling Chen, Chuang-Ye Hong, Wan-Jung Lu, Chun-Ming Shih and Ting-Lin Yen
Treatment of magnolol represents a new therapeutic strategy that may reduce the risk of vascular diseases associated with abnormal vascular smooth muscle cell (VSMC) migration or thrombin/protease-activated receptor 1 (PAR-1) activation.
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Wael El-Deeb, Olimpia Iacob, Mahmoud Fayez, Ibrahim Elsohaby, Abdulrahman Alhaider, Hermine V. Mkrtchyan, Abdelazim Ibrahim and Naser Alhumam
Cryptosporidium parvum (C. parvum) infection is one of the main causes of diarrhea in calves. The current study assessed the role of blood biomarkers (acute-phase proteins (APPs), procalcitonin, neopterin, cytokines, and oxidative stress in the pathogene...
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Yoon Hee Cho, Yeong Sook Yoon, Min Sun Koo, Wanseo Kim, Younglim Kho, Sunmi Kim, Yang Jee Kim, Haewon Choi, Eun Jeong Choi, Jae Whoan Koh, Kyoung Chul Chun and Young Ah Kim
Uterine leiomyomas are estrogen-dependent benign tumors with unknown etiologies. Phthalates are endocrine-disrupting chemicals and ubiquitous in the environment; thus, it has been suggested that they play a role in the development of uterine leiomyoma. W...
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Rashmi Kanagal-Shamanna, Weiqiang Zhao, Saroj Vadhan-Raj, Martin H. Nguyen, Michael H. Fernandez, L. Jeffrey Medeiros and Carlos E. Bueso-Ramos
Environmental exposure to benzene occurs through cigarette smoke, unleaded gasoline and certain types of plastic. Benzene is converted to hematotoxic metabolites by the hepatic phase-I enzyme CYP2E1, and these metabolites are detoxified by the phase-II e...
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Tingting Sui, Hongwu Yao, Tao Zhang, Jinze Li, Liangxue Lai and Zhanjun Li
The limb girdle muscular dystrophy type 2L (LGMD2L) is caused by mutations of the ANO5 gene in humans which encodes a 913 amino-acid integral membrane protein. Although cardiomyopathy has been reported in patients with an ANO5 mutation, the ANO5 mutant m...
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Wenyi Wang, Patrick C. L. Hui and Chi-Wai Kan
Atopic dermatitis (AD) is a common chronic inflammatory skin condition characterized by intense puritus and skin dryness. The pathogenesis for AD has not been fully understood to date. Complementary therapies are very popular as effective treatment for A...
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Maria Pia Ferraz
It is acknowledged that humans have a diverse and abundant microbial community known as the human microbiome. Nevertheless, our comprehension of the numerous functions these microorganisms have in human health is still in its early stages. Microorganisms...
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Diego Rubiales, Eleonora Barilli and Nicolas Rispail
Pea (Pisum sativum) stands out as one of the most significant and productive cool-season pulse crops cultivated worldwide. Dealing with biotic stresses remains a critical challenge in fully harnessing pea?s potential productivity. As such, dedicated rese...
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Adriana Mirela Tache, Laura Dorina Dinu and Emanuel Vamanu
Urinary tract infections (UTI) represent one of the most widespread infections, and frequent recurrent episodes, induced mostly by uropathogenic Escherichia coli, make them increasingly difficult to treat. Long-term antibiotic therapy is an effective app...
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Chang Kyu Lee, Dong Hwa Heo, Hungtae Chung, Eun Ji Roh, Anjani Darai, Jae Won Kyung, Hyemin Choi, Su Yeon Kwon, Basanta Bhujel and Inbo Han
Intervertebral disc (IVD) degeneration is a leading cause of chronic low back pain (LBP) that results in serious disability and significant economic burden. IVD degeneration alters the disc structure and spine biomechanics, resulting in subsequent struct...
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Dorina Lauritano, Giulia Moreo, Fedora Della Vella, Annalisa Palmieri, Francesco Carinci and Massimo Petruzzi
Background: It has been proven that the antihypertensive agent nifedipine can cause gingival overgrowth as a side effect. The aim of this study was to analyze the effects of pharmacological treatment with nifedipine on human gingival fibroblasts activity...
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Karam Allali, Jaouad Danane and Yang Kuang
A modified mathematical model describing the human immunodeficiency virus (HIV) pathogenesis with cytotoxic T-lymphocytes (CTL) and infected cells in eclipse phase is presented and studied in this paper. The model under consideration also includes a satu...
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Johannes L. Roos
Pág. 8 bladsye
The complex genetic architecture of schizophrenia is briefly described with reference to two contrasting (but conceptually related) hypotheses. There is reference to genome-wide association studies (GWAS) and the major histocompatibility complex (MH...
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Andrzej Prystupa, Pawel Kicinski, Dorota Luchowska-Kocot, Anna Blazewicz, Jaroslaw Niedzialek, Grzegorz Mizerski, Mariusz Jojczuk, Andrzej Ochal, Jaroslaw J. Sak and Wojciech Zaluska
According to some authors, serum selenium levels are strongly associated with the severity of liver diseases, including liver cirrhosis. The aim of this study was to determine the relationship between the concentration of selenium and pro-inflammatory an...
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Ida Casorelli, Cecilia Bossa and Margherita Bignami
Most antitumour therapies damage tumour cell DNA either directly or indirectly. Without repair, damage can result in genetic instability and eventually cancer. The strong association between the lack of DNA damage repair, mutations and cancer is dramatic...
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