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Balachandra Bandodkar, Radha Krishan Shandil, Jagadeesh Bhat and Tanjore S. Balganesh
After several years of limited success, an effective regimen for the treatment of both drug-sensitive and multiple-drug-resistant tuberculosis is in place. However, this success is still incomplete, as we need several more novel combinations to treat ext...
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Milad Salem, Aminollah Khormali, Arash Keshavarzi Arshadi, Julia Webb and Jiann-Shiun Yuan
Deep learning?s automatic feature extraction has proven its superior performance over traditional fingerprint-based features in the implementation of virtual screening models. However, these models face multiple challenges in the field of early drug disc...
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Yuan Qiao, Tingting Pan, Jiaze Li, Cheng Yang, Jiaxing Wen, Ke Zhong, Shanshan Wu, Fengyu Su and Yanqing Tian
Nanosensors for extracellular oxygen-sensing.
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Jun Xu,Jiming Ye
This review starts with outlining how science and technology evaluated from last century into high throughput science and technology in modern era due to the Nobel-Prize-level inventions of combinatorial chemistry, polymerase chain reaction, and high-thr...
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Jun Xu,Jiming Ye
This review starts with outlining how science and technology evaluated from last century into high throughput science and technology in modern era due to the Nobel-Prize-level inventions of combinatorial chemistry, polymerase chain reaction, and high-thr...
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Antonella Stanzione, Alessandro Polini, Velia La Pesa, Alessandro Romano, Angelo Quattrini, Giuseppe Gigli, Lorenzo Moroni and Francesca Gervaso
The developed thermoresponsive injectable hydrogels might be used as cell-delivery systems, 3D matrices for cell culture study, drug screening platforms, and for regenerative medicine applications.
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Diana Carolina Gutiérrez Monsalve,Miguel Cote Meléndez
Pág. 38 - 49
Los test de AUDIT (Alcohol Use Disorder Identification Test), DAST 10 (Drug Abuse Screening Test) y FAGERSTROM (dependencia a la Nicotina) son instrumentos para evaluar el consumo de Alcohol, Sustancias Psicoactivas y Uso de Nicotina, utilizados como mét...
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Christoph Gorgulla,Konstantin Fackeldey,Gerhard Wagner,Haribabu Arthanari
Structure-based virtual screening approaches have the ability to dramatically reduce the time and costs associated to the discovery of new drug candidates. Studies have shown that the true hit rate of virtual screenings improves with the scale of the scr...
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Christoph Gorgulla,Konstantin Fackeldey,Gerhard Wagner,Haribabu Arthanari
Structure-based virtual screening approaches have the ability to dramatically reduce the time and costs associated to the discovery of new drug candidates. Studies have shown that the true hit rate of virtual screenings improves with the scale of the scr...
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Giulia Degiacomi, Juan Manuel Belardinelli, Maria Rosalia Pasca, Edda De Rossi, Giovanna Riccardi and Laurent Roberto Chiarelli
The development and spread of Mycobacterium tuberculosis multi-drug resistant strains still represent a great global health threat, leading to an urgent need for novel anti-tuberculosis drugs. Indeed, in the last years, several efforts have been made in ...
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AM Bukar, MA Isa, HS Bello, AS Abdullahi
Pág. 147 - 152
The phytochemical screening and antibacterial activity of ethanolic and Methanolic leaves extract of Vernonia amygdalina against five clinical isolates (Staphylococcus aureus, E. coli, Pseudomonas species, Salmonella species and Proteus species) was dete...
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Mingxuan Che, Kui Yao, Chao Che, Zhangwei Cao and Fanchen Kong
The current global crisis caused by COVID-19 almost halted normal life in most parts of the world. Due to the long development cycle for new drugs, drug repositioning becomes an effective method of screening drugs for COVID-19. To find suitable drugs for...
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Laraibah Hamid, Abdulrhman Alsayari, Hidayatullah Tak, Suhail Ahmad Mir, Mohammad Ali Abdullah Almoyad, Shadma Wahab and Ghulam Nabi Bader
Helminth parasitic infections are a considerable constraint to the livestock industries worldwide. Nematode parasites cause the major proportion of harm to livestock. The infections caused are accountable for severe economic losses in cattle, goat and sh...
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Hristina Lebanova, Svetoslav Stoev, Emilia Naseva, Violeta Getova, Wei Wang, Ugne Sabale and Elina Petrova
Bulgaria is among the European Union (EU) countries with the highest burden of cervical cancers and life expectancy below the EU average. The majority of cervical cancer cases (more than 95%) are caused by the human papillomavirus (HPV). The aim of this ...
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Xingyu Li, Amit Madhukar Kudke, Felix Joseph Nepveux V and Yan Xu
This network-based pharmacology study intends to uncover the underlying mechanisms of cannabis leading to a therapeutic benefit and the pathogenesis for a wide range of diseases claimed to benefit from or be caused by the use of the cannabis plant. Canna...
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Titilayo Oyebola Omolola
Pág. 54 - 61
In recent times, medicinal plants are being greatly used ethnomedicinally for the management and treatment of diseases and health conditions. One of such medicinal plants is Tithonia diversifolia. This study aimed at determining the phytochemical, elemen...
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Dmitry S. Druzhilovskiy,Leonid A. Stolbov,Polina I. Savosina,Pavel V. Pogodin,Dmitry A. Filimonov,Alexander V. Veselovsky,Karen Stefanisko,Nadya I. Tarasova,Marc C. Nicklaus,Vladimir V. Poroikov
To improve the discovery of more effective and less toxic pharmaceutical agents, large virtual repositories of synthesizable molecules have been generated to increase the explored chemical-pharmacological space diversity. Such libraries include billions ...
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Dmitry S. Druzhilovskiy,Leonid A. Stolbov,Polina I. Savosina,Pavel V. Pogodin,Dmitry A. Filimonov,Alexander V. Veselovsky,Karen Stefanisko,Nadya I. Tarasova,Marc C. Nicklaus,Vladimir V. Poroikov
To improve the discovery of more effective and less toxic pharmaceutical agents, large virtual repositories of synthesizable molecules have been generated to increase the explored chemical-pharmacological space diversity. Such libraries include billions ...
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Alexey V. Sulimov,Danil C. Kutov,Vladimir B. Sulimov
Pág. 26 - 50
This review is based on the peer?reviewed research literature including the author?s own publications devoted to supercomputer docking. The general view on docking and its role at the initial stage of the rational drug design is presented. Molecules of m...
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Olamilekan Lanre Awotedu, P. O. Ogunbamowo, I. B. Emmanuel, I. O. Lawal
Pág. 28 - 34
Medicinal plants have great importance in African medicine and are also used as precursors in drug discovery. The medicinal value of plants lie in their bioactive constituents which usually allow them to fight against several diseases. Plant-based natura...
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