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Veysel Agan, Ismail Koyuncu, Fatma Zehra Agan and Mehmet Maruf Balos
This study investigated the antioxidant and anticancer properties, phenolic compounds, and content profile of Hypericum salsolifolium plant extracts prepared with different solvents. The total phenolic content, total flavonoid content, and antioxidant po...
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Ayad Rodhan Abbas, Bashar Saadoon Mahdi and Osamah Younus Fadhil
Anticancer peptides (ACPs) are short protein sequences; they perform functions like some hormones and enzymes inside the body. The role of any protein or peptide is related to its structure and the sequence of amino acids that make up it. There are 20 ty...
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Archana Lakshmanan, Balamuralikrishnan Balasubramanian, Viji Maluventhen, Arunkumar Malaisamy, Rathinasamy Baskaran, Wen-Chao Liu and Maruthupandian Arumugam
Fucoidan, a polymer derived from seaweed, poses a broad range of biological applications, and its potential medicinal benefits have been widely studied over the past decade. In this study, fucoidan was extracted from marine macroalga Sargassum ilicifoliu...
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Ali Irfan, Sami Ullah, Ayesha Anum, Nazish Jabeen, Ameer Fawad Zahoor, Hafza Kanwal, Katarzyna Kotwica-Mojzych and Mariusz Mojzych
The 1,2,3-thiadiazole moiety occupies a significant and prominent position among privileged heterocyclic templates in the field of medicine, pharmacology and pharmaceutics due to its broad spectrum of biological activities. The 1,2,3-thiadiazole hybrid s...
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Ali Irfan, Sajjad Ahmad, Saddam Hussain, Fozia Batool, Haseeba Riaz, Rehman Zafar, Katarzyna Kotwica-Mojzych and Mariusz Mojzych
Quinoxaline is a privileged pharmacophore that has broad-spectrum applications in the fields of medicine, pharmacology and pharmaceutics. Similarly, the sulfonamide moiety is of considerable interest in medicinal chemistry, as it exhibits a wide range of...
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Domenico Iacopetta, Jessica Ceramella, Camillo Rosano, Annaluisa Mariconda, Michele Pellegrino, Marco Sirignano, Carmela Saturnino, Alessia Catalano, Stefano Aquaro, Pasquale Longo and Maria Stefania Sinicropi
Transition metal complexes are attracting attention because of their various chemical and biological properties. In particular, the NHC-gold complexes represent a productive field of research in medicinal chemistry, mostly as anticancer tools, displaying...
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Myung Chul Lee, Shambhavi Pandey, Jae Woon Lim, Sangbae Park, Jae Eun Kim, Hyunmok Son, Jinsub Han, Hoon Seonwoo, Pankaj Garg and Jong Hoon Chung
Cisplatin, a representative anticancer drug used to treat cancer, has many adverse effects. In particular, it causes significant damage to the kidneys. Thus, many researchers have studied the delivery of drugs, such as cisplatin, to cancer areas using ta...
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Martyna Trukawka, Krzysztof Cendrowski, Wojciech Konicki and Ewa Mijowska
Herein, we present a facile synthesis route for the mesoporous silica nanoflakes on two types of templates and evaluate their potential as potential drug delivery systems. Silica materials are attractive due to their biocompatibility, low cytotoxicity, h...
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Mohammad Shahidul Islam, Abdullah Mohammed Al-Majid, Fardous F. El-Senduny, Farid A. Badria, A. F. M. Motiur Rahman, Assem Barakat and Yaseen A. M. M. Elshaier
A one-pot, single-step, and an atom-economical process towards the synthesis of highly functionalized spirooxindoles analogues was efficiently conducted to produce a satisfactory chemical yields (70?93%) with excellent relative diastereo-, and regio-sele...
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Hiroto Fujita, Yuka Kataoka and Masayasu Kuwahara
We have previously developed a bifunctional aptamer (bApt) binding to both human thrombin and camptothecin derivative (CPT1), and showed that bApt acts as a drug carrier under the phenomenon named selective oligonucleotide entrapment in fibrin polymers (...
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Ngan Tran, Minh Nguyen, Khanh PB Le, Nhi Nguyen, Quan Tran and Ly Le
Study of Euphorbia hirta Linn. extracts provide technical insight for functional food and drug development.
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Sarmistha Mitra, Pradeep Bhartiya, Neha Kaushik, Linh Nhat Nguyen, Rizwan Wahab, Sander Bekeschus, Eun Ha Choi and Nagendra Kumar Kaushik
Natural products with medicinal properties are among alternative therapies of interest due to their high body tolerance. We aimed to determine whether nonthermal gas plasma could enhance the medicinal value of Flammulina velutipes mushrooms. Generated ga...
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Sumangala Darsandhari, Biplav Shrestha, Ramesh Prasad Pandey, Sanghun Lee, Hye Jin Jung, Yeon Ju Kim and Jae Kyung Sohng
A glycoside derivative of compound K (CK) was synthesized by using a glycosyltransferase, and its biological activity was tested against various cancer-cell lines. A regiospecific, ß-1,4-galactosyltransferase (LgtB) converted 100% of 0.5 mmol CK into a g...
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Muhammad Nadeem, Muhammad Imran, Tanweer Aslam Gondal, Ali Imran, Muhammad Shahbaz, Rai Muhammad Amir, Muhammad Wasim Sajid, Tahira Batool Qaisrani, Muhammad Atif, Ghulam Hussain, Bahare Salehi, Elise Adrian Ostrander, Miquel Martorell, Javad Sharifi-Rad, William C. Cho and Natália Martins
Naturally occurring food-derived active ingredients have received huge attention for their chemopreventive and chemotherapy capabilities in several diseases. Rosmarinic acid (RA) is a caffeic acid ester and a naturally-occurring phenolic compound in a nu...
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Darakhshan Qaiser, Anurag Srivastava, Afshan Qaiser
Pág. 1 - 11
In the world, there are many systems of traditional medicine. Cancer is the major public health burden both in developing and developed countries. Around 50% of existing medicines for cancer treatment have plants origin. Anticancer property of some plant...
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Sitah Alanazi, ZabnAllah M. Alaizeri, Rashid Lateef, Nawal Madkhali, Abdullah Alharbi and Maqusood Ahamed
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Nilavukkarasi Mohandoss, Sangeetha Renganathan, Vijayakumar Subramaniyan, Punitha Nagarajan, Vidhya Elavarasan, Prathipkumar Subramaniyan and Sekar Vijayakumar
Capparis zeylanica leaf extract was employed in this work to create iron oxide nanoparticles (a-Fe2O3) using anhydrous ferric chloride. The UV spectrum, XRD, FT-IR, and FE-SEM with EDX methods were used to characterize the fabricated nanoparticles. The i...
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Suleiman Nafiu, Vitus Atanga Apalangya, Abu Yaya and Edward Benjamin Sabi
The electrical properties and characteristics of the armchair boron nitride nanotube (BNNT) that interacts with the curcumin molecule as an anticancer drug were studied using ab initio calculations based on density functional theory (DFT). In this study,...
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Chayut Subtaweesin, Wannipa Woraharn, Siriporn Taokaew, Nadda Chiaoprakobkij, Amornpun Sereemaspun and Muenduen Phisalaphong
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Luciana Mosca, Elisabetta Falvo, Pierpaolo Ceci, Elena Poser, Ilaria Genovese, Giulia Guarguaglini and Gianni Colotti
The ability of ferritin to bind and deliver metals and metal-based drugs to human neuroblastoma SH-SY5Y cells was studied. We used heavy chain (H) ferritin-based metal-containing nanocarriers to test whether these constructs, which are able to cross the ...
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