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Hyeonjin Cha, Jaeyoung Lee, Hee Ho Park and Ju Hyun Park
The generation of functional osteoblasts from human somatic cells could provide an alternative means of regenerative therapy for bone disorders such as osteoporosis. In this study, we demonstrated the direct phenotypic conversion of human dermal fibrobla...
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Xiaofang Zhang, Xiaodong Zhang, Bojun Yuan, Lijun Ren, Tianbao Zhang and Guocai Lu
Histone deacetylase inhibitors (HDACIs), such as vorinostat and panobinostat, have been shown to have active effects on many hematologic malignancies, including multiple myeloma and cutaneous T-cell lymphoma. Hydroxamate-based (Hb) HDACIs have very good ...
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Xiaodong Wang, Yuhang Guo, Yiru Wang, Yunling Peng, Hongwei Zhang and Jun Zheng
Drought stress presents a significant threat to the growth and development of maize. It is important to study the genes and mechanisms that contribute to drought tolerance. In this study, we identified ZmHDT103 (that encodes a histone deacetylase) by con...
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Rayanne H. N. Silva, Emanuel P. Magalhães, Rebeca C. Gomes, Yunierkis Perez-Castillo, Alice M. C. Martins and Damião P. de Sousa
Neglected tropical diseases (NTDs) cause thousands of deaths each year. Among these diseases, we find Chagas disease, whose etiologic agent is Trypanosoma cruzi. Piplartine is an alkamide present in various species of the genus Piper that possess trypano...
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