Resumen
Immune checkpoint inhibitors, including monoclonal antibodies directed against the programmed cell death-1 (PD-1)/programmed cell death ligand-1 (PD-L1) pathway or the cytotoxic T-lymphocyte antigen-4 (CTLA-4) pathway and the most recent lymphocyte-activation gene 3 (LAG-3)?blocking antibody, currently represent the standard of care for the treatment of a large number of solid tumors. However, the development of immune-related adverse events can limit the use of these beneficial agents in the clinical setting. It is of crucial importance to identify predictive biomarkers for those patients most likely benefiting from immunotherapy.