Resumen
Immunotherapy treatments have become one of the most popular options in cancer care. While their efficacy is well established, there is a significant risk of a variety of immune based side effects. These side effects, usually referred to as immune related adverse events, are well documented but poorly understood. To improve our understanding of the key cellular players involved in the development of these side effects, we have analyzed single cell sequencing data from PBMCs drawn from patients who developed skin immune related adverse events. Using that data, we have identified cellular population dynamic trends which point to potential mechanisms and pathways through which the side effects are occurring. This research is an important step in improving our understanding of the mechanisms that drive immune related adverse events.