Resumen
The nerve injury-induced protein 2 (NINJ2) is a cell adhesion molecule, but its biological function remains largely unexplored. Here, we show that NINJ2 can be induced by tumor suppressor p53. Interestingly, we also found that Ninj2 can in turn modulate p53 expression via repressing both wild-type and mutant p53 mRNA translation. Consequently, we found that the loss of NINJ2 inhibits cell growth in wild-type p53-containing cells but promotes cell growth in mutant p53-containing cells. Together, our data reveal a novel feedback loop between NINJ2 and p53 and that NINJ2 exerts an opposing role in cell growth depending on the p53 status.