Resumen
Stereotactic body radiotherapy (SBRT) offers a highly conformal tumoricidal dose of radiation and is an effective treatment for early stage non-small cell lung cancer (NSCLC). Single-fraction SBRT (SF-SBRT) produces cost-effective and comparable outcomes to hypofractionated SBRT regimens. There is a limited understanding of patient outcomes after SF-SBRT according to the histology of their early stage NSCLC. We investigated the survival and patterns of failure of patients with adenocarcinoma (ADC) and squamous cell carcinoma (SCC). Out of the 292 eligible patients, 174 and 118 patients were diagnosed with ADC and SCC, respectively. Patients with ADC were found to be significantly more likely to experience a distant failure compared to patients with SCC. No significant differences were found in overall survival, disease-free survival, local failure, or nodal failure based on histology.