Resumen
Notch signaling plays a context-dependent role in multiple cancer types by either promoting or suppressing tumor development. The role of the Notch receptors in the formation of brain tumors remains controversial. By exploiting conditional genetics and lineage tracing approaches to study unperturbed solid tumor growth in vivo, we uncover a tumor suppressor function for the Notch1 receptor in the forebrain and show that p53 and Notch1 cooperate to inhibit tumor formation.