Resumen
Diffuse midline gliomas are rare tumors of childhood characterized by a midline location, a diffuse-infiltrative growth pattern, and newly described genetic and epigenetic mutations. Since their first description at the beginning of the 20th century, they have been inoperable and carried a poor prognosis, with median survival shorter than two years. In the last decade, however, new hope is on the horizon thanks to new understanding of these tumors? biology and the development of novel, targeted therapeutics.