Resumen
There is growing evidence for the essential prognostic role of systemic inflammation within the tumor microenvironment (TME) and the nutritional status in cancer patients. Inflammation-based risk scores such as the Glasgow-Prognostic-Score (GPS), composed of C-reactive protein (CRP) and albumin levels at initial diagnosis, were shown to reflect the TME. This manuscript compares the prognostic impact of several well-established risk scores and ratios in the spectrum of neuroendocrine neoplasms of the gastro-entero-pancreatic (GEP-NEN) system. Our results highlight the prognostic capability of the GPS across the entire spectrum in GEP-NEN irrespective of histological grading or UICC stages and suggest its integration into more comprehensive models of risk stratification in the era of precision oncology.