Resumen
Proteolytic enzymes, such as matrix metalloproteinases, plasminogen activators and cathepsins, as well as non-proteolytic enzymatic partners, such as heparanase and hyaluron-idases, play key roles in the propagation and metastatic potential of cancer cells. This article aims to revisit the main functions of major matrix remodeling molecules and their effects in cancer meta-static potential. Moreover, the epigenetic regulation mechanisms of these molecules are discussed, in addition to recent advances in their pharmacological targeting. Finally, novel data from ongoing clinical trials on several cancer types are also provided. Overall, this review delves into the im-portance of matrix remodeling partners in cancer metastasis and explores their targeting as a promising therapeutic option for cancer management.