Resumen
Group 2 innate lymphoid cells (ILC2s), like other ILCs, are a new resident cell subset of innate immunity that provides the first line of defense against pathogens such as helminths and largely contributes to inflammation observed in allergic disorders and in some tumors. They are considered sentinel cells, which reside at the interface between host and external environment and are rapidly activated by signals deriving from tissue. Depending on the type of signals and their high plasticity, ILC2s exert both enhancing and regulatory activity on other tissue-resident cells, including tumor- and tumor-associated cells. The functional profile of ILC2s, their pro- or antitumor activity in preclinical studies and patients and the potential therapeutic approaches targeting ILC2s have been extensively reviewed.