Resumen
NKG2C and its ligand HLA-E represent key molecules for NK cell-mediated immune responsiveness. However, the impact of genetic variants in NKG2C and HLA-E on clinical outcomes of aggressive B-cell non-Hodgkin lymphoma patients (B-NHL) has not been clarified. In this study, we analyzed the distribution of NKG2C deletion status and HLA-E variants in 441 patients and 192 healthy individuals. Homozygous deletion of NKG2C (NKG2C-/-) was more often found in high-risk patients compared to patients with a lower risk and consequently was associated with reduced 2-year progression-free survival. The HLA-E*01:01 allele frequency was increased in B-NHL patients and was strongly related with complete remission. Our results show that absence of NKG2C and HLA-E allelic variations is predictive for B-NHL outcome; while carriers of HLA-E*01:01 are characterized by high, complete remission rates, NKG2C-/- was rare, but associated with poorer outcome. Prospective validation of our results identifies patients that may benefit from risk-adapted therapy.