Resumen
177Lu-DOTATATE is a radioactive drug that can treat advanced neuroendocrine tumors, a type of cancer. However, some patients do not benefit from 177Lu-DOTATATE treatment and there is an unmet need to identify such patients before they receive the treatment. Currently, each patient needs to have a positive result on a scan, such as 68Ga-DOTATATE PET/CT, prior to receiving 177Lu-DOTATATE treatment to verify that the drug can attack the patient?s cancer. This study used a semi-automatic analysis of 68Ga-DOTATATE PET/CT to predict the results of 177Lu-DOTATATE treatment. Having a large amount of cancer and/or a tumor with low signal on 68Ga-DOTATATE PET/CT predicted poor results of 177Lu-DOTATATE therapy. The semi-automatic nature of this method allows identification of patients at risk for treatment failure with little time and effort.