Resumen
CHUK/IKKa has emerged as a novel tumor suppressor in several organs of humans and mice. In general, activation of NF-?B promotes inflammation and tumorigenesis. IKKa reduction stimulates inflammatory responses including NF-?B?s targets and NF-?B-independent pathways for tumor promotion. Specific phenomena from genetically-modified mice and human TCGA database show the crosstalk between IKKa and NF-?B although their nature paths for normal organ development and the disease and cancer pathogenesis remains largely under investigation. In this review, we focus on the interplay between IKKa and NF-?B signaling during carcinogenesis. A better understanding of their relationship will provide insight into therapeutic targets of cancer.