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Inicio  /  Cancers  /  Vol: 16 Par: 1 (2024)  /  Artículo
ARTÍCULO
TITULO

Feasibility of Synchrotron-Based Ultra-High Dose Rate (UHDR) Proton Irradiation with Pencil Beam Scanning for FLASH Research

Lingshu Yin    
Umezawa Masumi    
Kan Ota    
Daniel M. Sforza    
Devin Miles    
Mohammad Rezaee    
John W. Wong    
Xun Jia and Heng Li    

Resumen

Ultra-high dose rate (UHDR) irradiation in proton therapy has mostly been performed using a cyclotron system so far. In this study, we present our approach to achieve an ultra-high dose rate for a clinical synchrotron proton therapy system and its dosimetric specifications. We demonstrated that it is feasible to adapt an existing clinical synchrotron-based proton therapy system and reach ~100 nA nozzle beam. UHDR dose rate (>40 Gy/s) was reached with the tested spot scanning patterns. The maximum dose per spill depends on the field size and is limited by the maximum charge extraction per spill. A beam monitoring ion chamber is currently being incorporated into the beam control system to improve system reproducibility and expand the irradiation area.

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