Resumen
Brainstem gliomas, particularly those with the H3K27M mutation, represent highly aggressive tumors with limited therapeutic avenues. The exploration of tumor cell antigens in this context becomes pivotal to identifying potential treatment targets. Through multiplex immunofluorescence analysis, we unveiled a robust correlation between the widespread expression of the IL13Ra2 membrane antigen in brainstem glioma and the presence of the H3.3K27M antigen. This compelling association underscores the promise of IL13Ra2 as a prime therapeutic target for treating brainstem glioma.