Resumen
The pathogenesis of CRC relies on complex interactions between developing cancer and surrounding tissue, including the immune system. One of the most abundant tumor-infiltrating cell populations is represented by tumor-associated macrophages (TAMs). TAMs play a detrimental role and are associated with a poor prognosis in many tumors and are characterized by an impaired antigen-presenting capability and by immunosuppressive activity. However, their role in CRC is still controversial. Our study aimed to elucidate how the colorectal cancer environment educates macrophages toward a pro-tumoral profile, exploiting them to escape the immune response. We demonstrate that both CRC cells and the extracellular matrix are actively involved in defining the macrophage profile, which is characterized by immunosuppressive activity and an impaired antigen-presenting ability. Dissecting the contribution of the tumor environment to the influence on the macrophage profile will provide additional knowledge for the development of new antitumor strategies.