Resumen
The anticancer effects reported in several heterocyclic derivatives of thiadiazole and thiazoline prompted us to construct functionalized new carbohydrate heterocycle entities and investigate their potential anticancer effects on several cancer cells. Here, we show that two novel heterocyclic moieties linked to functionalized carbohydrate with an anhydro scaffold skeleton caused the death of the investigated cancer cells. Interestingly, both N-adducts augmented the cytostatic effect on several cancer cell lines with totally different mechanisms of action. The thiazoline derivative responds via apoptosis through caspase activation and the thiadiazole derivative responds through oxidative stress, DNA damage, and necrosis at the micromolecular level.