Resumen
Polymorphous adenocarcinoma (PAC), the second most prevalent malignant tumour of the minor salivary glands, primarily affects the palate but can also involve the buccal mucosa. This systematic review investigates PAC?s clinical characteristics, emphasizing its presence in less-explored anatomical sites. Following PRISMA guidelines, we conducted a thorough search across PubMed, Scopus, and Web of Science, identifying and analysing 29 relevant studies. Among the 143 PAC patients included in the systematic review (62 males, 75 females, and 6 undefined, with a mean age of 57.4 ± 14.5 years), the palate was the predominant site affected by PAC (69.2%), followed by the buccal mucosa (8.4%). Additionally, we report two cases of PAC affecting the buccal mucosa, describing the mean features of an uncommon malignant neoplasm of the salivary glands. These findings underscore the significance of recognizing the buccal mucosa as a potential PAC site, urging careful examination during oral assessments due to the polymorphism and lack of pathognomonic signs.