Resumen
This review focusing on gender differences in the incidence of soft tissue and bone sarcomas. Sarcomas are rare cancers arising from mesenchymal tissues, which are different from the epithelial tissues and originate from the embryonic mesodermal layer. These cancers can be classified into bone or soft tissue sarcomas. Most sarcomas occur without known causes; however, certain genetic syndromes and environmental factors are known to be associated with these malignancies. Studies have indicated a male predominance in sarcoma incidence, which is also seen in other cancers like colorectal and lung cancers. Notably, childhood sarcomas exhibit significant gender differences, with a stronger association with the male sex, particularly in soft tissue sarcomas. The biological reasons for these sex differences are not well understood, and this review seeks to shed light on these underlying factors to aid in prevention and treatment strategies.