Resumen
Heat shock proteins (HSPs) play an important role in cellular metabolism and therefore are highly expressed in malignant brain tumors. In the current review, the authors assessed the prognostic value of HSPs in neuro-oncology and the possibility of employing these proteins as a target to develop novel therapeutic approaches. Indeed, several preclinical studies indicate the therapeutic potential of small molecular inhibitors of HSPs for targeting brain tumors when being applied as a monotherapy or in combination with other treatment approaches.