Resumen
Here, we showed the independent prognostic value of the four molecular subgroups?POLE-mutated, MMR-deficient, p53-abnormal, ?no specific molecular profile? (NSMP)?on a cohort of high-risk endometrial cancer patients. L1 neuronal cell adhesion molecule (L1CAM) expression could further stratify the NSMP subgroup, with L1CAM-positive patients having the worst prognosis compared to all other molecular subgroups. All NSMP/L1CAM-positive patients were ?early-relapsing?, showing a significantly shorter platinum-free interval than L1CAM-negative patients after adjuvant platinum-based chemotherapy. Since the NSMP is the most heterogeneous subgroup, we believe that L1CAM may represent a relevant candidate biomarker to complement both prognostic stratification and prediction of chemotherapy benefit in patients with high-risk endometrial cancer.