Resumen
Metabolic alterations (i.e., high glucose levels) enhance cancer cell aggressiveness by acting on tumor and on its environment. Mammary adipose tissue-derived mesenchymal stromal/stem cells (MAT-MSCs) stand in close proximity of breast cancer (BC) cells but have a still unclear role. We investigated whether changes in glucose concentration may impact on the interaction between human MAT-MSCs and BC cells. We provided evidence that in presence of cancer cells and high glucose levels, MAT-MSCs display pro-tumorigenic functions, while cancer cells become more aggressive. These results highlight that a metabolic control helps to reduce cancer outgrowth, at least in part preserving the functions of the adipose microenvironment.