Resumen
Our knowledge about the identity of many cancers has increased greatly during the last years and progress in their early identification as well as treatment options led to a net increase in the survival of many cancer patients. Unfortunately, gastric cancer does not belong to these cancers as it is still very badly treated and the chances to survive it are very low, less than 25%. This is mainly due to the fact that currently there are no possibilities to detect it at early stages and that tumors of gastric cancer patients seem all to be more or less different. In this respect, our knowledge about the differences between the gastric cancer from one patient to another is very limited. However, one family of proteins called ?Histone Deacetylases? or HDACs, in contrast, seem to be present or their function altered in gastric cancers. This review summarizes our current knowledge about their role in gastric cancer development and their potential as an early detection marker and target to develop new treatment options.