Resumen
The interaction between the highly aggressive triple-negative breast cancer, and the neutrophils is connected to the poor outcomes of this tumor. Using a wide array of cellular and molecular essays, we found that triple-negative breast cancer cells stressed out the neutrophil-like cells and reduced their viability in cell culture conditions. Furthermore, growing neutrophil-like cells with breast cancer cells enhanced the inflammatory activity of the neutrophil-like cells through the release and expression of chemical or structural inflammatory mediators. Given that cancer cells can exploit the active inflammatory milieu to the advantage of their growth and spread, targeting the crosstalk mechanisms that we illustrated here could help in defining potential therapeutic options in breast cancer management.