Resumen
An overwhelming percentage of deaths in solid tumors are caused by treatment failure due to the disease?s unresponsiveness when tumor cells tolerate treatment. Aggressive cancer contains tumors cells that are surrounded by many other non-tumor cells, including fibroblasts cells. These fibroblasts near tumor cells are converted by the tumor cells into specialized fibroblasts called cancer-associated fibroblasts that favor the growth of tumors. This review examines how cancer-associated fibroblasts interact with tumor cells, immune cells, and endothelial cells in aiding and abetting the development of resistance to different types of cancer therapy. As cancer-associated fibroblasts? function blocks the road to recovery, we need to neutralize their function for the clinical management of the disease to be successful. The knowledge about the role of cancer-associated fibroblasts in resisting therapy is fundamental to design an appropriate remedy to counteract drug resistance and improve the outcome of the disease.