Resumen
Colorectal cancer liver metastasis (CRLM) is the leading cause of colorectal cancer (CRC)-related deaths and remains poorly understood molecularly. Understanding the specific molecular characteristics of metastasis clearly bears the chance for improving treatment, or even preventing, this phenomenon. In this study, we aimed to investigate the expression status of Rap1 pathway-related genes in non-metastatic CRC patients and metastatic ones, as well as in primary CRCs and paired samples of those patients with liver metastases, which may help to support the definition of specific molecular characteristics or biomarkers of metastases.